IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration
نویسندگان
چکیده
منابع مشابه
IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration
BACKGROUND Neovascularization is an important repair mechanism in response to ischemic injury and is dependent on inflammation, angiogenesis and reactive oxygen species (ROS). IQGAP1, an actin-binding scaffold protein, is a key regulator for actin cytoskeleton and motility. We previously demonstrated that IQGAP1 mediates vascular endothelial growth factor (VEGF)-induced ROS production and migra...
متن کاملRAGE Regulates Immune Cell Infiltration and Angiogenesis in Choroidal Neovascularization
PURPOSE RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD). METHODS RAGE null (RAGE-/-) mice and age-matched wild type (WT) control mice underwent laser photocoagulation to...
متن کاملMonocyte/macrophage infiltration in tumors: modulators of angiogenesis.
The role of a tumor immune infiltrate in cancer progression and metastasis has been debated frequently. Although often considered to be associated with improved prognosis and leading to the enhanced survival of cancer patients, inflammatory cells have also been described to assist the tumor's capabilities to progress, proliferate, and metastasize. Tumor-associated macrophages (TAMs), for exampl...
متن کاملCritical Role of Endothelial Hydrogen Peroxide in Post-Ischemic Neovascularization
BACKGROUND Reactive oxygen species (ROS) play an important role in angiogenesis in endothelial cells (ECs) in vitro and neovascularization in vivo. However, little is known about the role of endogenous vascular hydrogen peroxide (H2O2) in postnatal neovascularization. METHODOLOGY/PRINCIPAL FINDINGS We used Tie2-driven endothelial specific catalase transgenic mice (Cat-Tg mice) and hindlimb is...
متن کاملMacrophage matrix metalloproteinase-9 regulates angiogenesis in ischemic muscle.
Angiogenesis is the formation of new blood vessels from existing endothelial cell–lined vessels. It occurs during normal development, and in many pathological conditions including tumor growth, would healing, inflammation, ischemia, and atherosclerosis. The development of new vessels can occur by abluminal sprouting of endothelial cells to form new branches or by the longitudinal splitting of e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0013440